Anti-Arrhythmics
(Last Updated - 8/8/2007)

-Based on the Vaughan Williams classification system

Class IA:
     -Modulate/block sodium channels --> inhibit phase 0 depolarization
     -Intermediate binding and dissociation from the receptor
          1) Quinidine
          2) Procainamide
          3) Disopyramide
Class IB:
     -Modulate/block sodium channels --> inhibit phase 0 depolarization
     -Most rapid binding and dissociation from the receptor
          1) Lidocaine
          2) Mexiletine
          3) Tocainide
          4) Phenytoin
Class IC:
     -Modulate/block sodium channels --> inhibit phase 0 depolarization
     -Slowest binding and dissociation from the receptor
          1) Flecainide
          2) Propafenone
          3) Moricizine
Class II:
     -Beta-Blockers
Class III:
     -Block potassium channels --> prolong repolarization, the APD and the refractory period --> prolong the QT interval
          1) Amiodarone --> the least pro-arrhythmic of the Class III agents
          2) Sotalol --> Class III agent with some beta-blocking properties too
          3) d-Sotalol --> pure Class III agent
          4) Dofetilide
          5) Ibutilide
          6) N-Acetyl Procainamide (NAPA)
          7) Azimilide
Class IV:
     -Non-Dihydropyridine Calcium Channel Blockers
          1) Verapamil
          2) Diltiazem


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