Anti-Arrhythmics
(Last Updated - 8/8/2007)
-Based on the Vaughan Williams classification system
Class IA:
-Modulate/block sodium channels --> inhibit phase 0 depolarization
-Intermediate binding and dissociation from the receptor
1) Quinidine
2) Procainamide
3) Disopyramide
Class IB:
-Modulate/block sodium channels --> inhibit phase 0 depolarization
-Most rapid binding and dissociation from the receptor
1) Lidocaine
2) Mexiletine
3) Tocainide
4) Phenytoin
Class IC:
-Modulate/block sodium channels --> inhibit phase 0 depolarization
-Slowest binding and dissociation from the receptor
1) Flecainide
2) Propafenone
3) Moricizine
Class II:
-Beta-Blockers
Class III:
-Block potassium channels --> prolong repolarization, the APD and the refractory period --> prolong the QT interval
1) Amiodarone --> the least pro-arrhythmic of the Class III agents
2) Sotalol --> Class III agent with some beta-blocking properties too
3) d-Sotalol --> pure Class III agent
4) Dofetilide
5) Ibutilide
6) N-Acetyl Procainamide (NAPA)
7) Azimilide
Class IV:
-Non-Dihydropyridine Calcium Channel Blockers
1) Verapamil
2) Diltiazem
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